BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-07456

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Protein Array, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CPTC-BCL2L2-2

Concentration

0.2 mg/ml

View all Bcl-w Antibodies »

Product Summary for BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2)

Immunogen

Recombinant human full-length BCL-W/BCL2L2 protein (Uniprot: Q92843)

Localization

Ubiquitous cytoplasmic expression.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP3-08778)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C.

Scientific Data Images for BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2)

Western Blot: BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2) [NBP3-07456]

Western Blot: BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2) [NBP3-07456]

Western Blot: BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2) [NBP3-07456] - Western Blot Analysis of PC-3, HEK293, MCF-7, HEPG2 and U87 cells using BCL-W/BCL2L2 Mouse Monoclonal Antibody (CPTC-BCL2L2-2).
Protein Array: BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2) [NBP3-07456]

Protein Array: BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2) [NBP3-07456]

Protein Array: BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2) [NBP3-07456] - Analysis of Protein Array containing more than 19,000 full-length human proteins using BCL-W/BCL2L2 Mouse Monoclonal Antibody (CPTC-BCL2L2-2).

Applications for BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2)

Application
Recommended Usage

Western Blot

1-2 ug/ml
Application Notes
ELISA: For coating, order antibody without BSA
Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Bcl-w

Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.

Long Name

B Cell Lymphoma/Leukemia w

Alternate Names

BCL2L2, Bclw

Gene Symbol

BCL2L2

UniProt

Q92843

Additional Bcl-w Products

Product Documents for BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BCL-W/BCL2L2 Antibody (CPTC-BCL2L2-2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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