BCR Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89137

Novus Biologicals, part of Bio-Techne
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NBP1-89137
NBP1-89137-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all BCR Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VDPVGFAEAWKAQFPDSEPPRMELRSVGDIEQELERCKASIRRLEQEVNQERFRMIYLQTLLAKEKKSYDRQRW

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for BCR Antibody

Immunocytochemistry/ Immunofluorescence: BCR Antibody [NBP1-89137]

Immunocytochemistry/ Immunofluorescence: BCR Antibody [NBP1-89137]

Immunocytochemistry/Immunofluorescence: BCR Antibody [NBP1-89137] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
Immunohistochemistry-Paraffin: BCR Antibody [NBP1-89137]

Immunohistochemistry-Paraffin: BCR Antibody [NBP1-89137]

Immunohistochemistry-Paraffin: BCR Antibody [NBP1-89137] - Staining of human thyroid gland shows strong cytoplasmic and extra cellular positivity in glandular cells.

Applications for BCR Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BCR

The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4).

Long Name

Breakpoint Cluster Region

Alternate Names

ALL, PHL

Gene Symbol

BCR

Additional BCR Products

Product Documents for BCR Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BCR Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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