BCR [p Tyr276] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24460

Novus Biologicals, part of Bio-Techne
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NBP2-24460
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Key Product Details

Species Reactivity

Validated:

Human, Primate

Predicted:

Bovine (94%), Mouse (100%), Rat (94%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

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Product Summary for BCR [p Tyr276] Antibody

Immunogen

A portion of human phospho Bcr protein containing a phosphorylated tyrosine residue at position 276 was used as the immunogen for this phospho antibody.

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: 100% homologous in human ,chimpanzee, monkey and mouse; rat (94%), cow(94%) chicken (89%), zebrafish (84%), xenopus (81%).

Modification

p Tyr276

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for BCR [p Tyr276] Antibody

Western Blot: BCR [p Tyr276] Antibody [NBP2-24460]

Western Blot: BCR [p Tyr276] Antibody [NBP2-24460]

Western Blot: Bcr [p Tyr276] Antibody [NBP2-24460] - Analysis of phospho Bcr (Y276) in recombinant fusion protein containing 1) a phosphorylated tyrosine at position 276 and 2) an unphosphorylated tyrosine at position 276, using Bcr phospho antibody at 0.01 ug/ml. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for BCR [p Tyr276] Antibody

Application
Recommended Usage

Western Blot

0.01-1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.1 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: BCR

The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4).

Long Name

Breakpoint Cluster Region

Alternate Names

ALL, PHL

Gene Symbol

BCR

Additional BCR Products

Product Documents for BCR [p Tyr276] Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for BCR [p Tyr276] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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