beta-2 Adrenergic R/ADRB2 Antibody (13D6) [Janelia Fluor® 635]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12008JF635

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Janelia Fluor 635

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # 13D6

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all beta-2 Adrenergic R/ADRB2 Antibodies »

Product Summary for beta-2 Adrenergic R/ADRB2 Antibody (13D6) [Janelia Fluor® 635]

Immunogen

This antibody was raised by immunizing mice with beta-2 adrenergic receptor.

Specificity

13D6 antibody recognizes human beta-2 adrenergic receptor. It was reported that this antibody recognizes extracellualr domains of the receptor (Han et al., 2012). Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for beta-2 Adrenergic R/ADRB2 Antibody (13D6) [Janelia Fluor® 635]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: beta-2 Adrenergic R/ADRB2

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Long Name

Beta-2 Adrenergic Receptor

Alternate Names

ADRB2, ADRB2R, B2AR, beta-2 AdrenergicR, beta2 AdrenergicR

Gene Symbol

ADRB2

Additional beta-2 Adrenergic R/ADRB2 Products

Product Documents for beta-2 Adrenergic R/ADRB2 Antibody (13D6) [Janelia Fluor® 635]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for beta-2 Adrenergic R/ADRB2 Antibody (13D6) [Janelia Fluor® 635]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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