c-Abl [p Tyr245] Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-13326

Novus Biologicals, part of Bio-Techne
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NBP3-13326
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all c-Abl Antibodies »

Product Summary for c-Abl [p Tyr245] Antibody

Immunogen

Carrier-protein conjugated synthetic peptide surrounding phospho Tyr245 of mouse c-Abl. The exact sequence is proprietary.

Modification

p Tyr245

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

123 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Centrifuge briefly prior to opening.

Scientific Data Images for c-Abl [p Tyr245] Antibody

Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]

Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]

Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326] - Untreated (-) and treated (+) K562 whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with c-Abl (phospho Tyr245) antibody (NBP3-13326) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]

Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]

Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with c-Abl (phospho Tyr245) antibody (NBP3-13326) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.
c-Abl [p Tyr245] Antibody

Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326] -

Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326] - Various whole cell extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with c-Abl antibody (NBP3-13326) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
View 1 more images

Applications for c-Abl [p Tyr245] Antibody

Application
Recommended Usage

Western Blot

1:500-1:3000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: c-Abl

c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.

Long Name

Abelson Murine Leukemia Viral Oncogene Homolog 1

Alternate Names

ABL1, BCR-ABL1, bcr/abl, cAbl, JTK7

Gene Symbol

ABL1

Additional c-Abl Products

Product Documents for c-Abl [p Tyr245] Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for c-Abl [p Tyr245] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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