c-Abl Products
c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.
47 results for "c-Abl" in Products
47 results for "c-Abl" in Products
c-Abl Products
c-Abl (Abelson murine leukemia viral homolog 1) is a cytosolic member of the ABL subfamily, protein tyrosine kinase family of enzymes. It is ubiquitously expressed, and participates in multiple processes such as cell migration, actin reorganization, DNA damage response and apoptosis. Human c-Abl (I-B) is 1149 amino acids (aa) in length. It is myristoylated on Gly2 and contains one SH3 domain (aa 80-140), an SH2 domain (aa 146-236), a protein kinase region (aa 261-512), three NLS's (aa 620-634; 726-739; 778-791), one DNA-binding region (aa 888-988), an NES motif (aa 1109-1119) and an actin F-binding domain (aa 1120-1149). There is one alternate splice form (I-A) that contains a 26 aa substitution for the N-terminal 45 amino acids. In chronic myelogenous leukemia, c-Abl is fused to the Bcr gene product, resulting in the production of a constitutively active tyrosine kinase.
Highly potent pan-Src/Bcr-Abl inhibitor
| Alternate Names: | BMS-354825 |
| Chemical Name: | N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western |
Dual Src-Abl inhibitor; antiproliferative
| Alternate Names: | SKI-606 |
| Chemical Name: | 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile |
| Purity: | ≥99% |
Src family kinase inhibitor; also inhibits c-Abl
| Alternate Names: | 1-NA-PP 1 |
| Chemical Name: | 1-(1,1-Dimethylethyl)-3-(1-naphthalenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥99% (HPLC) |
Ras signaling inhibitor; inhibits Ack1 and GCK
| Chemical Name: | N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide |
| Purity: | ≥98% (HPLC) |
| Source: | E. coli |
| Accession #: | P00519.4 |
| Applications: | EnzAct |
| Reactivity: | Human, Mouse |
| Details: | Mouse IgG1 Monoclonal Clone #8E9 |
| Applications: | IHC, WB, ICC/IF, IP |
![Western Blot: c-Abl Antibody (8E9) [NBP2-49695]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-8E9-Western-Blot-NBP2-49695-img0004.jpg "Western Blot: c-Abl Antibody (8E9) [NBP2-49695]")
Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit
| Alternate Names: | Gleevec,CGP 57148B |
| Chemical Name: | 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90289]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-90289-img0006.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90289]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90287]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-90287-img0004.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP1-90287]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]](https://resources.bio-techne.com/images/products/c-Abl-[p-Tyr245]-Antibody-Western-Blot-NBP3-13326-img0003.jpg "Western Blot: c-Abl [p Tyr245] Antibody [NBP3-13326]")
Potent inhibitor of Abl T315l mutant and wild-type Abl kinases
| Chemical Name: | 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent EGFR and VEGFR inhibitor
| Chemical Name: | 6-[4-[(4-Ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
BCR-ABL1 kinase PROTAC® Degrader
| Chemical Name: | (2S,4R)-1-((S)-3,3-Dimethyl-2-(2-(2-(4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenoxy)ethoxy)acetamido)butanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective Src tyrosine kinase family inhibitor; anticancer; antiviral; orally bioavailable
| Alternate Names: | AZD 0530 |
| Chemical Name: | N-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4-quinazolinamine |
| Purity: | ≥98% (HPLC) |
Potent multi-kinase and pan-Bcr-Abl inhibitor
| Alternate Names: | Ponatinib |
| Chemical Name: | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ELISA, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP2-99737]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-99737-img0001.jpg "Immunocytochemistry/ Immunofluorescence: c-Abl Antibody [NBP2-99737]")
Selective allosteric inhibitor of Bcr-Abl; analog of GNF 2 (Cat. No. 4399)
| Chemical Name: | N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide |
| Purity: | ≥98% (HPLC) |
Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases
| Chemical Name: | N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine |
| Purity: | ≥98% (HPLC) |
Potent, selective Src family kinase inhibitor
| Chemical Name: | 1-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![c-Abl [p Tyr245] Antibody](https://resources.bio-techne.com/images/products/nbp3-23313_rabbit-c-abl-p-tyr245-pab-199202312523642.jpg "Western Blot: c-Abl [p Tyr245] Antibody [NBP3-23313] -")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: c-Abl Antibody [NBP1-90288]](https://resources.bio-techne.com/images/products/c-Abl-Antibody-Immunohistochemistry-NBP1-90288-img0004.jpg "Immunohistochemistry-Paraffin: c-Abl Antibody [NBP1-90288]")
| Applications: | WB |
![Western Blot: c-Abl Overexpression Lysate [NBL1-07208]](https://resources.bio-techne.com/images/products/c-Abl-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-07208-img0002.jpg "Western Blot: c-Abl Overexpression Lysate [NBL1-07208]")
| Applications: | WB |
![Western Blot: c-Abl Overexpression Lysate [NBL1-07209]](https://resources.bio-techne.com/images/products/c-Abl-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-07209-img0002.jpg "Western Blot: c-Abl Overexpression Lysate [NBL1-07209]")
| Applications: | AC |