c-jun [p Ser63] Antibody (SR1842)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21583

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21583-100ul
NBP3-21583-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1842

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all c-Jun Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-c-jun [Ser63] (Uniprot #: P05412)

Modification

p Ser63

Specificity

Detects endogenous levels of total phospho-c-jun [Ser63]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

48 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for c-jun [p Ser63] Antibody (SR1842)

Immunohistochemistry: c-jun [p Ser 63] Antibody (SR1842) [NBP3-21583] -

Immunohistochemistry: c-jun [p Ser 63] Antibody (SR1842) [NBP3-21583] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using NBP3-21583.

Western Blot: c-jun [p Ser 63] Antibody (SR1842) [NBP3-21583] -

Western Blot: c-jun [p Ser 63] Antibody (SR1842) [NBP3-21583] - Western blot analysis using NBP3-21583 in NIH/3T3 cell lysate treated with Anisomycin.

Immunocytochemistry/Immunofluorescence: c-jun [p Ser 63] Antibody (SR1842) [NBP3-21583] -

Immunocytochemistry/Immunofluorescence: c-jun [p Ser 63] Antibody (SR1842) [NBP3-21583] - Immunofluorescent analysis of HeLa cells treated with anisomycin, using NBP3-21583.

Applications for c-jun [p Ser63] Antibody (SR1842)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunohistochemistry

1:50-1:200

Immunohistochemistry-Paraffin

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: c-Jun

The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies.

Long Name

Cellular Repressor of E1A-stimulated Genes/Transcription Factor AP-1

Alternate Names

cJun, JUN

Gene Symbol

JUN

Additional c-Jun Products

Product Documents for c-jun [p Ser63] Antibody (SR1842)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for c-jun [p Ser63] Antibody (SR1842)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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