CACNA2D1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86683

Novus Biologicals, part of Bio-Techne
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NBP1-86683-25ul
NBP1-86683
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Cited:

Human, Mouse

Predicted:

Mouse (98%), Rat (98%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CACNA2D1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: QPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKLEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CACNA2D1 Antibody

Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683]

Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683]

Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683] - Staining in human skeletal muscle and pancreas tissues using NBP1-86683 antibody. Corresponding CACNA2D1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683]

Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683]

Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683] - Staining of human cerebellum, cerebral cortex, pancreas and skeletal muscle using Anti-CACNA2D1 antibody NBP1-86683 (A) shows similar protein distribution across tissues to independent antibody NBP1-86682 (B).
Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683]

Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683]

Immunohistochemistry-Paraffin: CACNA2D1 Antibody [NBP1-86683] - Staining of human cerebellum shows weak positivity in neuropil.
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Applications for CACNA2D1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CACNA2D1

The CACNA2D1 gene encodes a voltage-dependent calcium channel subunit alpha-2/delta-1 protein that exists in 5 isoforms: isoform 1: 1,103 amino acids long, 124 kDA; isoform 2: 1,091 amino acids long, 123 kDA; isoform 3: 1,086 amino acids long, 122 kDA; isoform 4: 1,079 amino acids long, 121 kDA; and isoform 5: 1,084 amino acids long, 122 kDA. These proteins are critical in calcium current density and in activation and inactivation kinetics of the calcium channel. Additionally, these proteins function in excitation-contraction coupling. The CACNA2D1 gene participates in transcription of the CREB pathway, the caspase cascade, Fc-GammaR pathway, BMP and PDGF pathways, MAPK signaling pathway, and cardiac muscle contraction. It is known to interact with genes DLG4, CACNA1C, CACNA1D, CACNA1F, and YWHAB. The CACNA2D1 gene is associated with neuroblastoma, heart blocks, liver disease, parkinson's disease, dementia, malignant hyperthermia susceptibility, lambert-eaton myasthenic syndrome, timothy syndrome, peripheral neropathy, and fatty liver disease.

Long Name

Voltage-dependent calcium channel subunit alpha-2/delta-1

Alternate Names

CACNL2A, CCHL2A, MHS3

Gene Symbol

CACNA2D1

Additional CACNA2D1 Products

Product Documents for CACNA2D1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CACNA2D1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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