Cadherin-17 Antibody (10C12) - Humanized
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28819
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
ELISA, Flow Cytometry, Functional
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Human IgG1 Clone # 10C12
Concentration
LYOPH mg/ml
Product Specifications
Immunogen
CDH17 / Cadherin-17
Clonality
Monoclonal
Host
Human
Isotype
IgG1
Endotoxin Level
< 0.001EU/ug,determined by LAL method.
Description
Expressed from CHO. The heavy chain type is IgG1, and the light chain type is hukappa. It has a predicted MW of 143.68kDa.
Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
Scientific Data Images for Cadherin-17 Antibody (10C12) - Humanized
ELISA: Cadherin-17 Antibody (10C12) - Humanized[NBP3-28819] -
Immobilized human Cadherin-17, His Tag at 2 ug/mL can bind Cadherin-17 Antibody (10C12) - Humanized, EC50=0.00468 ug/mL.
Functional: Cadherin-17 Antibody (10C12) - Humanized[NBP3-28819] -
The endocytosis ratio 10C12 by Human CDH17 HEK293 increased with the increase of antibody concentration, and the Internalization Rate (%) reached 80% at antibody concentration of 2 nM.
In vivo assay: Cadherin-17 Antibody (10C12) - Humanized[NBP3-28819] -
10C12 inhibited the tumor growth of COLO205 on nude mice. The result showed significant anti-tumor effects, with an tumor inhibition rate (TGI) of 70.0% at 5 mpk at D26.Applications for Cadherin-17 Antibody (10C12) - Humanized
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Functional
Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A purified
Reconstitution
Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.
Formulation
Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
Preservative
No Preservative
Concentration
LYOPH mg/ml
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C.
Background: Cadherin-17
Additional Cadherin-17 Products
Product Documents for Cadherin-17 Antibody (10C12) - Humanized
Product Specific Notices for Cadherin-17 Antibody (10C12) - Humanized
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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