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Cadherin-6/KCAD Antibody (HKT288)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28075

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
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NBP3-28075-100ug
NBP3-28075-50ug

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # HKT288

Concentration

LYOPH mg/ml

Product Specifications

Immunogen

CDH6 / K-Cadherin

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Cadherin-6/KCAD Antibody (HKT288)

Cadherin-6/KCAD Antibody (HKT288)

ELISA: Cadherin-6/KCAD Antibody (HKT288)[NBP3-28075] -

Immobilized Cyno Cadherin-6/KCAD His at 2 ug/mL can bind Cadherin-6/KCAD Antibody (HKT288), EC50=0.006944 ug/mL.
Cadherin-6/KCAD Antibody (HKT288)

Functional: Cadherin-6/KCAD Antibody (HKT288)[NBP3-28075] -

The endocytosis ratio HKT288 by Hu-CDH6-HEK293(A6) increased with the increase of antibody concentration, and the Internalization Rate (%) reached 93% at antibody concentration of 2 nM.
Cadherin-6/KCAD Antibody (HKT288)

Functional: Cadherin-6/KCAD Antibody (HKT288)[NBP3-28075] -

HKT288 induced OVCAR3 Luciferase activity was evaluated using huCD16a(V158)-NF-AT-Jurkat Reporter Cell. The EC50 was approximately 0.6792 nM.

Applications for Cadherin-6/KCAD Antibody (HKT288)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Cadherin-6/KCAD

K Cadherin encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.

Alternate Names

Cadherin6, CDH6, K-Cadherin

Gene Symbol

CDH6

UniProt

Additional Cadherin-6/KCAD Products

Product Documents for Cadherin-6/KCAD Antibody (HKT288)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Cadherin-6/KCAD Antibody (HKT288)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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