Calsyntenin-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85706

Novus Biologicals, part of Bio-Techne
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NBP1-85706
NBP1-85706-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Calsyntenin-1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNS

Reactivity Notes

Mouse (87%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Calsyntenin-1 Antibody

Western Blot: Calsyntenin-1 Antibody [NBP1-85706]

Western Blot: Calsyntenin-1 Antibody [NBP1-85706]

Western Blot: Calsyntenin-1 Antibody [NBP1-85706] - Analysis in human cell line CAPAN-2.
Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP1-85706]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP1-85706]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP1-85706] - Staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells.

Applications for Calsyntenin-1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04 - 0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Calsyntenin-1

CLSTN1 (calsyntenin 1) is mainly expressed in brain tissues and to a lesser degree in heart, skeletal muscle and the placenta. It accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques. The protein induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. It is involved in complex formation with APBA2 and APP, stabilizing APP metabolism and enhancing APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. It may also modulate calcium-mediated postsynaptic signals.

Alternate Names

Alcadein-alpha, Calsyntenin1, CLSTN1, CS1, CSTN1, XB31alpha

Gene Symbol

CLSTN1

Additional Calsyntenin-1 Products

Product Documents for Calsyntenin-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Calsyntenin-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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