Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28124

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG4 Clone # nimacimab

Concentration

LYOPH mg/ml

View all Cannabinoid R1/CB1/CNR1 Antibodies »

Product Specifications

Immunogen

CB1 / CNR1

Clonality

Monoclonal

Host

Human

Isotype

IgG4

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.

Also known as 'nimacimab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized

Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized

ELISA: Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized[NBP3-28124] -

Immobilized Human CB1 VLP at 5 ug/mL (30 uL/well) can bind Monoclonal Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized, The EC50 was approximately 0.04092 µg/ml.
Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized

Flow Cytometry: Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized[NBP3-28124] -

Human CB1 / CNR1 EGFP HEK293 Cell Line were stained with Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized and negative control protein respectively, washed and then followed by APC and analyzed with FACS, EC50=0.028 ug/mL.

Applications for Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Cannabinoid R1/CB1/CNR1

CB1 Cannabinoid receptor is associated with the regulation of cognition, memory, and motor activity. The CB1 receptor mediates cannabinoid-induced CNS effects and the addictive behavior experienced by users of marijuana. Three splice variants that are produced by alternative splicing have been identified for this gene. CB1 has been reported primarily in the brain and, to a lower extent, in peripheral tissues including adrenal, heart, lung, prostate, uterus, ovary, testis, bone marrow, thymus, and tonsil. ESTs have been isolated from brain, embryo, heart/melanocyte/uterus, lung, placenta, testis, tonsil, and vessel libraries.

Long Name

Cannabinoid Receptor 1

Alternate Names

CANN6, CannabinoidR1, CB-R, CB1, CB1A, CB1K5, CB1R, CNR1, SKR6R

Gene Symbol

CNR1

UniProt

Q96F85 (Human)

Additional Cannabinoid R1/CB1/CNR1 Products

Product Documents for Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Cannabinoid R1/CB1/CNR1 Antibody (nimacimab) - Humanized

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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