carabin Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76806

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all carabin Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Carabin. The immunogen is located within the last 50 amino acids of Carabin. Amino Acid Squence: PEEPRPPRRKPQTRGKT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for carabin Antibody - BSA Free

Western Blot: carabin AntibodyBSA Free [NBP1-76806]

Western Blot: carabin AntibodyBSA Free [NBP1-76806]

Western Blot: carabin Antibody [NBP1-76806] - Daudi cell lysate with Carabin antibody at (A) 1 and (B) 2 ug/ml.
Immunohistochemistry-Paraffin: carabin Antibody - BSA Free [NBP1-76806]

Immunohistochemistry-Paraffin: carabin Antibody - BSA Free [NBP1-76806]

Immunohistochemistry-Paraffin: carabin Antibody [NBP1-76806] - Human spleen tissue with Carabin antibody at 2.5 ug/ml.
carabin Antibody - BSA Free

Western Blot: carabin Antibody - BSA Free [NBP1-76806] -

Western Blot: carabin Antibody - BSA Free [NBP1-76806] - Western blot analysis of carabin in Daudi cell lysate with carabin antibody at (A) 1 and (B) 2 u/mL.
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Applications for carabin Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: carabin

Antigen binding by the T-cell receptor (TCR) is one of the critical first steps in the immune response, triggering a cascade of signaling pathways that ultimately lead to T-cell activation. Screening a yeast two-hybrid screen of a human T-cell cDNA library with calcineurin, a protein phosphatase involved in multiple signaling pathways including T-cell activation, resulted in the identification of Carabin, a member of the TBC1 domain family of proteins, as a calcineurin-binding protein. Unlike other members of the TBC1 domain protein family which are thought to have a role in regulating cell growth and differentiation, further experiments demonstrated that Carabin is part of a negative regulatory loop for the intracellular TCR signaling pathway as well as an inhibitor of the Ras signaling pathway, suggesting that Carabin may also mediate crosstalk between calcineurin and Ras. Carabin antibody does not recognize TBC1D10A or TBC1D10B. Carabin is known to exist in multiple isoforms.

Alternate Names

carabin, FLJ00332, MGC46488, TBC1 domain family member 10C, TBC1 domain family, member 10C

Gene Symbol

TBC1D10C

UniProt

NP_940919 (Human)

Additional carabin Products

Product Documents for carabin Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for carabin Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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