CARD11/CARMA1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-80110

Novus Biologicals, part of Bio-Techne
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NBP2-80110
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all CARD11/CARMA1 Antibodies »

Product Specifications

Immunogen

N-terminal human CARD11/CARMA1 (aa 1-221 containing the CARD domain).

Specificity

Recognizes human and mouse CARD11/CARMA1. Detects a band of ~130Dka by Western blot.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CARD11/CARMA1 Antibody

Immunocytochemistry/ Immunofluorescence: CARD11/CARMA1 Antibody [NBP2-80110]

Immunocytochemistry/ Immunofluorescence: CARD11/CARMA1 Antibody [NBP2-80110]

Immunocytochemistry/Immunofluorescence: CARD11/CARMA1 Antibody [NBP2-80110] - Analysis of CARMA1 using CARD11/CARMA1, pAb (AL220) (Prod. No. NBP2-80110).

Applications for CARD11/CARMA1 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS containing 10% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CARD11/CARMA1

CARD11 belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Long Name

Caspase Recruitment Domain-containing Protein 11

Alternate Names

BIMP3, CARMA1

Gene Symbol

CARD11

Additional CARD11/CARMA1 Products

Product Documents for CARD11/CARMA1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CARD11/CARMA1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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