Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Caspase-12 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid peptide near the amino terminus of murine Caspase-12. The immunogen is located within the first 50 amino acids of Caspase-12. Amino Acid Squence: AARRTHERDPIYKIKG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Caspase-12 Antibody - BSA Free

Western Blot: Caspase-12 AntibodyBSA Free [NBP2-31179]

Western Blot: Caspase-12 AntibodyBSA Free [NBP2-31179]

Western Blot: Caspase-12 Antibody [NBP2-31179] - Western blot analysis of caspase-12 in (A) human and (B) mouse spleen tissue lysates with caspase-12 antibody at 1 ug/mL.
Immunohistochemistry-Paraffin: Caspase-12 Antibody - BSA Free [NBP2-31179]

Immunohistochemistry-Paraffin: Caspase-12 Antibody - BSA Free [NBP2-31179]

Immunohistochemistry-Paraffin: Caspase-12 Antibody [NBP2-31179] - Human heart tissue with caspase-12 antibody at 10 ug/mL.

Applications for Caspase-12 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

10 ug/ml

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspase-12

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene, CASP12, is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. (provided by RefSeq)

Alternate Names

CASP12, Caspase12

Gene Symbol

CASP12

UniProt

O08736

Additional Caspase-12 Products

Product Documents for Caspase-12 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Caspase-12 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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