Key Product Details

Species Reactivity

Human, Mouse, Rat, Sheep

Applications

Flow Cytometry, Immunoblotting, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

DyLight 405 (Excitation = 400 nm, Emission = 420 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 7C8

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Caveolin-1 Antibodies »

Product Specifications

Immunogen

Intracellular membrane protein-containing vesicles (containing GLUT4) from rat adipocytes

Localization

Cell Membrane

Specificity

This is specific for caveolin alpha and beta proteins.

Marker

Caveolae Marker, Endosome Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Caveolin-1 Antibody (7C8) [DyLight 405]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunoblotting

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Caveolin-1

Caveolin-1 (CAV1) belongs to caveolin family which encodes integral membrane proteins of 21kD-24 kD size and forms structural component of caveolar membrane in caveolae, the specialized domains of plasma membrane implicated in sequestration of lipids/proteins. Caveolin-1 as well as caveolin-2 are abundantly expressed in fibroblasts, differentiated adipocytes, smooth/skeletal muscle and in endothelial cells, whereas, caveolin-3 expression is limited to muscular tissues. Caveolin 1 interacts with a broad range of proteins that includes GLIPR2, NOSTRIN, SNAP25, syntaxin, rotavirus A NSP4, DPP4, CTNNB1, CDH1, JUP, BMX and BTK. It interacts directly with G-protein's alpha subunits for regulating their activity and is also implicated in costimulatory signal essential for TCR-mediated activation of T-cells. Caveolin 1 binding to DPP4 induces T-cell proliferation as well as activation of NFkB in TCR/CD3-dependent manner and also recruits CTNNB1 to caveolar membranes for regulating CTNNB1-mediated signal transduction via WNT pathway. Defects in caveolin-1 have been linked to congenital generalized lipodystrophy type 3 (CGL3), and it is also implicated in cardiovascular/pulmonary diseases and its role in carcinogensis is context/cancer dependent, wherein it suppresses genes that favor tumor development, and at the same time it promotes focal adhesion turnover as well as migration of metastatic cancer cells.

Alternate Names

CAV1, Caveolin1, MSTP085, VIP21

Gene Symbol

CAV1

Additional Caveolin-1 Products

Product Documents for Caveolin-1 Antibody (7C8) [DyLight 405]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Caveolin-1 Antibody (7C8) [DyLight 405]



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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