Caveolin-3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-28917

Novus Biologicals, part of Bio-Techne
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NBP1-28917
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine

Predicted:

Bovine (100%), Canine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Caveolin-3 Antibodies »

Product Specifications

Immunogen

Peptide with sequence EHTDLEAQIVKDIH-C corresponding to N-Terminus according to NP_203123.1.

Epitope

N Terminus

Specificity

Reported variants represent identical protein (NP_001225.1; NP_203123.1).

Marker

Muscle Specific Caveolae Marker, T-tubule Marker

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Caveolin-3 Antibody

Western Blot: Caveolin-3 Antibody [NBP1-28917]

Western Blot: Caveolin-3 Antibody [NBP1-28917]

Western Blot: Caveolin-3 Antibody [NBP1-28917] - Caveolin 3 in human heart lysate (35 ug protein in RIPA buffer) using this antibody at 0.3 ug/mL. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: Caveolin-3 Antibody [NBP1-28917]

Immunohistochemistry-Paraffin: Caveolin-3 Antibody [NBP1-28917]

Immunohistochemistry-Paraffin: Caveolin-3 Antibody [NBP1-28917] - Staining of human skeletal muscle with primary antibody at 3.8 ug/mL. Antigen retrieval with citrate buffer pH 6, AP-staining.
Western Blot: Caveolin-3 Antibody [NBP1-28917]

Western Blot: Caveolin-3 Antibody [NBP1-28917]

Western Blot: Caveolin-3 Antibody [NBP1-28917] - Mouse (A) and Rat (B) heart lysates (35 ug protein in RIPA buffer). Antibody at 0.3 ug/mL. Detected by chemiluminescence.
View 1 more images

Applications for Caveolin-3 Antibody

Application
Recommended Usage

Immunohistochemistry

3 - 5 ug/mL

Immunohistochemistry-Paraffin

3 - 5 ug/mL

Peptide ELISA

Detection limit 1:4000

Western Blot

0.1 - 0.3 ug/mL
Application Notes
WB: Approx. 23 kDa band observed in human, mouse and rat heart lysates and 20 kDa band in porcine heart and skeletal muscle lysates (calculated MW of 17.3 kDa band according to NP_203123.1). IHC-P: Human skeletal muscle shows peripheral staining of fibres.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Caveolin-3

This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq]

Alternate Names

CAV3, Caveolin3, LGMD1C, LQT9, M-caveolin

Entrez Gene IDs

859 (Human); 12391 (Mouse); 29161 (Rat)

Gene Symbol

CAV3

UniProt

NP_203123.1 (Human)

Additional Caveolin-3 Products

Product Documents for Caveolin-3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Caveolin-3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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