CCL4/MIP-1 beta Antibody (SR1111)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21790

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21790-100ul
NBP3-21790-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1111

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CCL4/MIP-1 beta Antibodies »

Product Summary for CCL4/MIP-1 beta Antibody (SR1111)

Immunogen

A synthesized peptide derived from human CCL4/MIP-1 beta (Uniprot #: P13236)

Specificity

Detects endogenous levels of total CCL4/MIP-1 beta

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

12 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for CCL4/MIP-1 beta Antibody (SR1111)

Western Blot: CCL4/MIP-1 beta Antibody (SR1111) [NBP3-21790] -

Western Blot: CCL4/MIP-1 beta Antibody (SR1111) [NBP3-21790] - Western blot analysis using NBP3-21790 in (1) THP-1 cell lysate; (2) THP-1 cell treated with PMA+LPS+Brefeldin A.

Applications for CCL4/MIP-1 beta Antibody (SR1111)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:1000-1:5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CCL4/MIP-1 beta

CCL4/MIP-1 beta is a beta chemokine that is secreted at sites of inflammation by activated leukocytes, lymphocytes, vascular endothelial cells, and pulmonary smooth muscle cells. It attracts a variety of immune cells to sites of microbial infection as well as to other pathologic inflammation such as allergic asthma and ischemic myocardium. CCL4 is secreted from activated monocytes as a heterodimer with CCL3/MIP-1 alpha. It signals through CCR5, and an N-terminally trimmed form additionally interacts with CCR1 and CCR2. In humans, the ability of CCL4 to bind CCR5 inhibits the cellular entry of M-tropic HIV-1 which utilizes CCR5 as a coreceptor.

Alternate Names

Exodus-3, MIP-1 beta, MIP1 beta

Gene Symbol

CCL4

Additional CCL4/MIP-1 beta Products

Product Documents for CCL4/MIP-1 beta Antibody (SR1111)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CCL4/MIP-1 beta Antibody (SR1111)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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