CCM2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86730

Novus Biologicals, part of Bio-Techne
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NBP1-86730
NBP1-86730-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CCM2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LHSDDSSTKVDIKETYEVEASTFCFPESVDVGGASPHSKTISESELSASATELLQDYMLTLRTKLSSQEIQQFAALLHEYRNGA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CCM2 Antibody

Immunocytochemistry/ Immunofluorescence: CCM2 Antibody [NBP1-86730]

Immunocytochemistry/ Immunofluorescence: CCM2 Antibody [NBP1-86730]

Immunocytochemistry/Immunofluorescence: CCM2 Antibody [NBP1-86730] - Staining of human cell line U-2 OS shows localization to mitochondria. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: CCM2 Antibody [NBP1-86730]

Immunohistochemistry-Paraffin: CCM2 Antibody [NBP1-86730]

Immunohistochemistry-Paraffin: CCM2 Antibody [NBP1-86730] - Staining in human lymph node and pancreas tissues using anti-CCM2 antibody. Corresponding CCM2 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: CCM2 Antibody [NBP1-86730]

Immunohistochemistry-Paraffin: CCM2 Antibody [NBP1-86730]

Immunohistochemistry-Paraffin: CCM2 Antibody [NBP1-86730] - Staining of human lymph node shows high expression.
View 1 more images

Applications for CCM2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

Reported in scientific literature (PMID: 26417067)
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CCM2

p16 INK4a is a tumor suppressor protein. It is a specific inhibitor of Cdk 4 / Cdk 6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16 INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16 INK4a abnormalities is higher in tumor derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16 INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia.

Alternate Names

C7orf22OSM, cerebral cavernous malformation 2, Cerebral cavernous malformations 2 protein, chromosome 7 open reading frame 22, malcavernin, MGC4067, MGC4607, MGC74868

Gene Symbol

CCM2

Additional CCM2 Products

Product Documents for CCM2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CCM2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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