CCNDBP1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1133

Novus Biologicals, part of Bio-Techne
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NB100-1133
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all CCNDBP1 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-NRIKELTQSELEL corresponding to C-Terminus according to NP_036274.3, NP_411241.1.

Specificity

This antibody is expected to recognise both human isoforms of this protein.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CCNDBP1 Antibody

Immunohistochemistry-Paraffin: CCNDBP1 Antibody [NB100-1133]

Immunohistochemistry-Paraffin: CCNDBP1 Antibody [NB100-1133]

Immunohistochemistry-Paraffin: CCNDBP1 Antibody [NB100-1133] - staining.

Applications for CCNDBP1 Antibody

Application
Recommended Usage

Immunohistochemistry

3 - 6 ug/ml

Immunohistochemistry-Paraffin

3 - 6 ug/ml

Peptide ELISA

Detection limit 1:32000
Application Notes
WB: Preliminary experiments gave an approx. 55 kDa band in K562 lysate at 0.5 ug/ml, this band was successfully blocked by incubation with the immunizing peptide. Please note that currently we cannot find an explanation in scientific literature for the band we observe given the predicted MW of approx. 41 kDa and 27 kDa band according to NP_036274; NP_411241. IHC-P: Human prostate shows textured cytoplasm staining with emphasis on the luminal side of the secretory cells in the glands.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CCNDBP1

CCNDBP1 was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Two alternatively spliced variants, which encode distinct isoforms, have been reported.

Alternate Names

cyclin D-type binding-protein 1, cyclin-D1-binding protein 1, DIP1HHM Protein, D-type cyclin-interacting protein 1, GCIPgrap2 cyclin interacting protein, Grap2 and cyclin-D-interacting protein, HHM, Human homolog of Maid, MAID protein

Entrez Gene IDs

23582 (Human)

Gene Symbol

CCNDBP1

UniProt

NP_036274 (Human)

Additional CCNDBP1 Products

Product Documents for CCNDBP1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CCNDBP1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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