CD21 Antibody (CL14552)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26866

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL14552

Concentration

1 mg/ml

View all CD21 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a Synthetic Peptide of P20023. Actual immunogen sequence is proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for CD21 Antibody (CL14552)

CD21 Antibody (CL14552)

Immunohistochemistry-Paraffin: CD21 Antibody (CL14552) [NBP3-26866]

Staining of human tonsil shows strong membranous positivity in germinal center cells.
CD21 Antibody (CL14552)

Immunohistochemistry-Paraffin: CD21 Antibody (CL14552) [NBP3-26866]

Staining of human small intestine shows strong membranous positivity in a subset of lymphoid cells.
CD21 Antibody (CL14552)

Immunohistochemistry-Paraffin: CD21 Antibody (CL14552) [NBP3-26866]

Analysis in human tonsil and skeletal muscle tissues. Corresponding RNA-seq data are presented for the same tissues.
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Applications for CD21 Antibody (CL14552)

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD21

CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.

Alternate Names

C3DR, CD21, CR2

Gene Symbol

CR2

Additional CD21 Products

Product Documents for CD21 Antibody (CL14552)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CD21 Antibody (CL14552)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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