CD3 epsilon Antibody (TR66) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-97446

Novus Biologicals, part of Bio-Techne
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NBP1-97446-0.025mg
NBP1-97446
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Functional, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # TR66

Format

BSA Free

Concentration

1.0 mg/ml

View all CD3 epsilon Antibodies »

Product Specifications

Immunogen

Cloned human helper T cell line.

Specificity

Recognizes the epsilon-chain of human CD3.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for CD3 epsilon Antibody (TR66) - BSA Free

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunocytochemistry/ Immunofluorescence

1:10-1:2000

Immunoprecipitation

1:10-1:500
Application Notes
Detects endogenous protein by FC, ICC and IP.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD3 epsilon

CD3 epsilon is a subunit of CD3. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits: CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.

Alternate Names

CD3e

Gene Symbol

CD3E

Additional CD3 epsilon Products

Product Documents for CD3 epsilon Antibody (TR66) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CD3 epsilon Antibody (TR66) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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