CD98 Antibody (HBJ127) [Janelia Fluor® 525]
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81109JF525
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Applications
Block/Neutralize, ELISA, Functional, Immunocytochemistry/ Immunofluorescence
Label
Janelia Fluor 525
Antibody Source
Recombinant Monoclonal Rabbit IgG Kappa Clone # HBJ127
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Summary for CD98 Antibody (HBJ127) [Janelia Fluor® 525]
Immunogen
HBJ127 was obtained from hybridomas generated by the fusion of mouse myeloma cells and spleen cells from mice which had been immunized with T24 hyman bladder cancer cells.
Specificity
HBJ127 binds to the CD98 heavy chain at an epitope consisting of residues AFS (aa 442-444) (Itoh et al, 2007). The antibody has not been shown to cross-react with other species. CD98 is expressed at high levels on monocytes and at very low level on peripheral blood T and B lymphocytes, splenocytes, NK cells and granulocytes. CD98 is a disulfide-linked and glycosylated type II integral membrane protein. This protein has roles in normal and neoplastic cell growth and is required for the function of light chain amino acid transporters. It is also involved in sodium-independent transport of large neitral amino acids and in guiding and targeting LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, CD98 acts as an arginine/glutamine exchanger.
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG Kappa
Applications for CD98 Antibody (HBJ127) [Janelia Fluor® 525]
Application
Recommended Usage
Block/Neutralize
Optimal dilutions of this antibody should be experimentally determined.
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Functional
Optimal dilutions of this antibody should be experimentally determined.
Immunocytochemistry/ Immunofluorescence
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: CD98
Alternate Names
4F2, 4F2hc, CD98, CH98hc, FRP-1, SLC3A2
Gene Symbol
SLC3A2
Additional CD98 Products
Product Documents for CD98 Antibody (HBJ127) [Janelia Fluor® 525]
Product Specific Notices for CD98 Antibody (HBJ127) [Janelia Fluor® 525]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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