CDC37 [p Ser13] Antibody (SR1889)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21571

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21571-100ul
NBP3-21571-50ul
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Human, Mouse, Rat

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1889

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CDC37 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human phospho-CDC37 [Ser13] (Uniprot #: Q16543)

Modification

p Ser 13

Specificity

Detects endogenous levels of total phospho-CDC37 [Ser13]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for CDC37 [p Ser13] Antibody (SR1889)

Western Blot: CDC37 [p Ser 13] Antibody (SR1889) [NBP3-21571] -

Western Blot: CDC37 [p Ser 13] Antibody (SR1889) [NBP3-21571] - Western blot analysis using NBP3-21571 in (1) Jurkat cell lysate treated with Alkaline Phosphatase; (2) Jurkat cell lysate.

Applications for CDC37 [p Ser13] Antibody (SR1889)

Application
Recommended Usage

Immunoprecipitation

1:50

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CDC37

In S. cerevisiae, Cdc37 has been shown to be an important regulator of cell division cycle through its action on cyclin-dependent kinases (CDK's). Cdc37 has also been associated with signaling pathways and kinases unrelated to cell cycle control, including v-Src, casein kinase II, MPS1 kinase and the sevenless receptor tyrosine kinase. Interestingly, HSP90 has also been shown to be associated with many of the same cellular targets as Cdc37. It has now been shown that Cdc37 is the same protein previously described as p50 which has been found to be associated with many of the same proteins as HSP90. Among others, Cdc37/p50 has been found complexed with Src-family kinases (Fyn, Yes, Fes, Lck & Fgr), Raf and pp60v-src. More recently, Cdc37 has been shown to be a chaperone independently and in concert with HSP90. In fact, Cdc37 is necessary for the binding of HSP90 to Cdk4.

Alternate Names

CDC37 (cell division cycle 37, S. cerevisiae, homolog), CDC37 cell division cycle 37 homolog, CDC37 cell division cycle 37 homolog (S. cerevisiae), CDC37A, cell division cycle 37 homolog (S. cerevisiae), Hsp90 chaperone protein kinase-targeting subunit, hsp90 co-chaperone Cdc37, p50Cdc37

Gene Symbol

CDC37

Additional CDC37 Products

Product Documents for CDC37 [p Ser13] Antibody (SR1889)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CDC37 [p Ser13] Antibody (SR1889)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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