Cdk4 is encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Long Name

Cyclin-dependent Kinase 4

Alternate Names

CMM3, PSK-J3

Gene Symbol

CDK4

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Product Documents for CDK4 Antibody (6D10) [Janelia Fluor® 549]

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Product Specific Notices for CDK4 Antibody (6D10) [Janelia Fluor® 549]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CDK4 Antibody (6D10) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-42642JF549

Key Product Details

Species Reactivity

Applications

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Antibody Source

Concentration

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Product Specifications

Immunogen

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Applications for CDK4 Antibody (6D10) [Janelia Fluor® 549]

ELISA

Western Blot

Formulation, Preparation, and Storage

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Formulation

Preservative

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Background: CDK4