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CHIP/STUB1 Antibody (006)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-90115

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
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NBP2-90115-100ul
NBP2-90115-50ul

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 006

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

This antibody was obtained from a rabbit immunized with purified, recombinant Human CHIP/STUB1 isoform 1 (Uniprot#: Q9UNE7-1; Met 1-Tyr 303).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C-8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for CHIP/STUB1 Antibody (006)

Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115]

Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115]

Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115] - Immunochemical staining of human STUB1 in human pancreas with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115]

Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115]

Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115] - Immunochemical staining of human STUB1 in human skeletal muscle with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).
Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115]

Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115]

Immunohistochemistry-Paraffin: CHIP/STUB1 Antibody (006) [NBP2-90115] - Immunochemical staining of human STUB1 in human placenta with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections).

Applications for CHIP/STUB1 Antibody (006)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:100-1:500

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CHIP/STUB1

STUB1/CHIP is an E3 ubiquitin ligase and co-chaperone of heat-shock protein 70 (Hsp70). STUB1/CHIP interacts with Hsp70 to monitor protein folding and direct misfolded proteins for proteasomal degradation. It has been found to also associate with Hsp90 to remove phosphorylated protein tau, a protein that accumulates in the brains of Alzheimers and Down's syndrome patients. STUB1/CHIP has been reported to also have intrinsic chaperone activity and recognize non-native proteins in response to heat stress. In this way, STUB1/CHIP has been shown to be a direct chaperone for p53. Alternate names for STUB1/CHIP include carboxy terminus of Hsp70-interacting protein, STIP1 homology and U-box containing protein 1, CLL-associated antigen KW-8 antigen, serologically defined colon cancer antigen 7, heat shock protein A binding protein 2, NY-CO-7, HSPABP2, and SDCCAG7.

Long Name

C-terminus of Hsc70 Interacting Protein

Alternate Names

HSPABP2, NY-CO-7, SDCCAG7, STUB1, UBOX1

Gene Symbol

STUB1

Additional CHIP/STUB1 Products

Product Documents for CHIP/STUB1 Antibody (006)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for CHIP/STUB1 Antibody (006)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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