CIB1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-25301

Novus Biologicals, part of Bio-Techne
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NBP3-25301
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (98%), Rat (99%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CIB1 Antibodies »

Product Summary for CIB1 Antibody

Immunogen

This antibody has been engineered to specifically recognize the recombinant protein CIB1 using the following amino acid sequence: DIKSHYAFRIFDFDDDGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISRSPDFASSF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CIB1 Antibody

CIB1 Antibody Immunohistochemistry-Paraffin: CIB1 Antibody [NBP3-25301]

Immunohistochemistry-Paraffin: CIB1 Antibody [NBP3-25301]

Staining of human kidney shows nuclear positivity in cells i tubules and glomeruli.
CIB1 Antibody Western Blot: CIB1 Antibody [NBP3-25301]

Western Blot: CIB1 Antibody [NBP3-25301]

Analysis in human cell line RT-4.

Applications for CIB1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 µg/ml
Application Notes
For IHC-Paraffin, we recommend using Heat-Induced Epitope Retrieval (HIER) with a pH level of 6. This optimized retrieval method ensures the best results for your experiments.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CIB1

CIB1(also designated calcium and integrin binding 1 or calmyrin),with 191-amino acid protein(about 21kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining.CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha(IIb)beta(3) integrin and several serine/threonine kinases and potentially modulates their function.CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha(IIb) cytoplasmic domain of platelet integrin alpha(IIb)beta(3). CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.

Long Name

Calcium and Integrin Binding 1

Alternate Names

Calmyrin, CIBP, KIP, PRKDCIP, SIP2-28

Gene Symbol

CIB1

Additional CIB1 Products

Product Documents for CIB1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CIB1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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