CIP2A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-48710

Novus Biologicals, part of Bio-Techne
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NBP2-48710
NBP2-48710-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CIP2A Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: KMPWQSSNHSFPTSIKCLTPHLKDGVPGLNIEELIEKLQSGMVVKDQICDVRISDIMDVYEMKLSTLASKESRLQDLLETKALALAQADRLIAQHRCQRTQAET

Reactivity Notes

Mouse (80%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CIP2A Antibody

Immunocytochemistry/ Immunofluorescence: CIP2A Antibody [NBP2-48710]

Immunocytochemistry/ Immunofluorescence: CIP2A Antibody [NBP2-48710]

Immunocytochemistry/Immunofluorescence: CIP2A Antibody [NBP2-48710] - Analysis of human cell line A-431 shows positivity in plasma membrane & cytoplasm.
Immunohistochemistry-Paraffin: CIP2A Antibody [NBP2-48710]

Immunohistochemistry-Paraffin: CIP2A Antibody [NBP2-48710]

Immunohistochemistry-Paraffin: CIP2A Antibody [NBP2-48710] - Staining of human testis shows moderate cytoplasmic positivity in cells in seminiferous ducts.

Applications for CIP2A Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CIP2A

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Alternate Names

Cancerous inhibitor of PP2A, CIP2A, FLJ12850, KIAA1524, MGC163436, p90, p90 autoantigen, protein CIP2A

Gene Symbol

CIP2A

Additional CIP2A Products

Product Documents for CIP2A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CIP2A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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