Claudin-3 Antibody (12B2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26656

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # 12B2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Claudin-3 Antibodies »

Product Specifications

Immunogen

Recombinant Human Claudin-3 protein [UniProt O15551]

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Scientific Data Images for Claudin-3 Antibody (12B2)

Claudin-3 Antibody (12B2)

ELISA: Claudin-3 Antibody (12B2) [NBP3-26656] -

ELISA: Claudin-3 Antibody (12B2) [NBP3-26656] - The Binding Activity of Claudin-3 with Claudin-3 Antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human Claudin-3 at 10 ug/mL can bind Claudin-3 Antibody, the EC50 is 23.62-34.37 ng/mL.VLPs is negative control.

Applications for Claudin-3 Antibody (12B2)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50% Glycerol, 0.01M PBS, PH 7.4

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: Claudin-3

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and variations of Claudin expression may have an important role in transcellular transport through tight junctions. In rat liver, claudin-3 is uniformly expressed, whereas in the pancreas, claudin-3 is expressed in junctions of the duct epithelia and junctions of acinar cells. Claudin-3 binds the peptide toxin Clostridium perfringens enterotoxin (CPE) at the cell surface via the second extracellular loop of claudin-3. The gene encoding human claudin-3 maps to chromosome 7q11.23.

Alternate Names

Claudin3, CLDN3, CPE-R 2, CPETR2, HRVP1

Gene Symbol

CLDN3

Additional Claudin-3 Products

Product Documents for Claudin-3 Antibody (12B2)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Claudin-3 Antibody (12B2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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