Claudin-5 Antibody (SR3444)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27772

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-27772-100ul
NBP3-27772-50ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR3444

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Claudin-5 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Claudin-5 (Uniprot #: O00501)

Specificity

Detects endogenous levels of total Claudin-5

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

20 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Claudin-5 Antibody (SR3444)

Western Blot: Claudin-5 Antibody (SR3444) [NBP3-27772] -

Western Blot: Claudin-5 Antibody (SR3444) [NBP3-27772] - Western blot analysis of Claudin-5 expression in human fetal brain lysate.

Applications for Claudin-5 Antibody (SR3444)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Claudin-5

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specific regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrome, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.The human claudin-5 gene maps to chromosome 22q11.21.

Alternate Names

AWAL, BEC1, Claudin5, CLDN5, CPETRL1, TMDVCF, TMVCF1

Gene Symbol

CLDN5

Additional Claudin-5 Products

Product Documents for Claudin-5 Antibody (SR3444)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Claudin-5 Antibody (SR3444)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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