Coagulation Factor XI Antibody (garadacimab) - IgG4SP

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28438

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-28438-100ug
NBP3-28438-50ug
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG4 Clone # garadacimab

Concentration

LYOPH mg/ml

View all Coagulation Factor XI Antibodies »

Product Specifications

Immunogen

F12 / Factor XII

Clonality

Monoclonal

Host

Human

Isotype

IgG4

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG4SP, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.

Also known as 'garadacimab'.

IgG4SP is human IgG4 with S228P mutation.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Applications for Coagulation Factor XI Antibody (garadacimab) - IgG4SP

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Coagulation Factor XI

Factor XI encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq]

Alternate Names

coagulation factor XI, EC 3.4.21, EC 3.4.21.27, FXIPlasma thromboplastin antecedent, MGC141891, PTA

Gene Symbol

F11

UniProt

P00748 (Human)

Additional Coagulation Factor XI Products

Product Documents for Coagulation Factor XI Antibody (garadacimab) - IgG4SP

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Coagulation Factor XI Antibody (garadacimab) - IgG4SP

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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