Cofilin 2 Antibody (6G9)

Novus Biologicals, part of Bio-Techne | Catalog # H00001073-M03

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 6G9

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Cofilin 2 Antibodies »

Product Specifications

Immunogen

CFL2 (NP_068733, 57 a.a. ~ 166 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. VGDIGDTVEDPYTSFVKLLPLNDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASSKDAIKKKFTGIKHEWQVNGLDDIKDRSTLGEKLGGNVVVSLEGKPL

Specificity

CFL2 - cofilin 2 (muscle)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Cofilin 2 Antibody (6G9)

Western Blot: Cofilin 2 Antibody (6G9) [H00001073-M03]

Western Blot: Cofilin 2 Antibody (6G9) [H00001073-M03]

Western Blot: Cofilin 2 Antibody (6G9) [H00001073-M03] - Analysis of CFL2 expression in HeLa (Cat # L013V1).
Immunocytochemistry/ Immunofluorescence: Cofilin 2 Antibody (6G9) [H00001073-M03]

Immunocytochemistry/ Immunofluorescence: Cofilin 2 Antibody (6G9) [H00001073-M03]

Immunocytochemistry/Immunofluorescence: Cofilin 2 Antibody (6G9) [H00001073-M03] - Analysis of monoclonal antibody to CFL2 on HeLa cell. Antibody concentration 10 ug/ml
Immunohistochemistry-Paraffin: Cofilin 2 Antibody (6G9) [H00001073-M03]

Immunohistochemistry-Paraffin: Cofilin 2 Antibody (6G9) [H00001073-M03]

Immunohistochemistry-Paraffin: Cofilin 2 Antibody (6G9) [H00001073-M03] - Analysis of monoclonal antibody to CFL2 on formalin-fixed paraffin-embedded human skeletal muscle. Antibody concentration 8 ug/ml
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Applications for Cofilin 2 Antibody (6G9)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IF, IHC-P and ELISA.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Cofilin 2

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. (Gillett et al., 1996 [PubMed 8800436]). Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN; MIM 609114), all of which regulate actin-filament dynamics (Bamburg et al., 1999 [PubMed 10461190]; Maciver and Hussey, 2002). The CFL2 gene encodes a skeletal muscle-specific isoform (Vartiainen et al., 2002 [PubMed 11809832]) localized to the thin filaments, where it exerts its effect on actin, in part through interactions with tropomyosins (Ono and Ono, 2002 [PubMed 11901171]).[supplied by OMIM]

Alternate Names

cofilin 2 (muscle), Cofilin, muscle isoform, cofilin-2, NEM7

Entrez Gene IDs

1073 (Human)

Gene Symbol

CFL2

OMIM

601443 (Human)

UniProt

NP_068733 (Human)

Additional Cofilin 2 Products

Product Documents for Cofilin 2 Antibody (6G9)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Cofilin 2 Antibody (6G9)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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