Complement C4b Antibody (C1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-41465

Novus Biologicals, part of Bio-Techne
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NBP3-41465
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Key Product Details

Species Reactivity

Human, Porcine

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # C1

Format

BSA Free

Concentration

1 mg/ml

View all Complement C4b Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Human Complement C4b (Uniprot#: P0C0L5; Gln19-Leu333 (Uniprot#: P0C0L5)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for Complement C4b Antibody (C1) - BSA Free

Complement C4b Antibody (C1)

Immunohistochemistry-Paraffin: Complement C4b Antibody (C1) [NBP3-41465] -

Immunohistochemistry-Paraffin: Complement C4b Antibody (C1) [NBP3-41465] - DAB staining on IHC-P; Samples: Human Liver Tissue; Primary Ab: 30ug/ml NBP3-41465; Second Ab: 2ug/mL HRP-Linked Caprine Anti-Mouse IgG Polyclonal Antibody

Applications for Complement C4b Antibody (C1) - BSA Free

Application
Recommended Usage

Immunohistochemistry

5-20ug/mL

Immunohistochemistry-Paraffin

5-20ug/mL

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Format

BSA Free

Preservative

0.05% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Complement C4b

C4b encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Alternate Names

basic C4, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4B1, C4B12, C4B2, C4B3, C4FMGC164979, CH, Chido form of C4, CO4C4B5, complement C4-B, complement C4B1a, complement component 4B, complement component 4B (Chido blood group), CPAMD3FLJ60561, EC 2.1.1.144, EC 2.7.11

Gene Symbol

C4B

Additional Complement C4b Products

Product Documents for Complement C4b Antibody (C1) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Complement C4b Antibody (C1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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