Complement Component C3aR Antibody (hC3aRZ1)

Novus Biologicals, part of Bio-Techne | Catalog # NB100-64835

Novus Biologicals, part of Bio-Techne
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NB100-64835
NB100-64835-0.025mg
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # hC3aRZ1

Concentration

1 mg/ml

View all Complement Component C3aR Antibodies »

Product Specifications

Immunogen

Recombinant human C3aR protein

Specificity

NB100-64835 recognizes the receptor for human complement component C3a (C3aR), a 55kD cell surface protein of the rhodopsin family of G protein-coupled seven-transmembrane receptors. C3a is an anaphylatoxin, which is a potent proinflammatory mediator that possesses immunoregulatory properties. C3a regulates inflammatory functions by binding to the C3a receptor. C3aR is expressed on various tissues and leucocytes including basophils, neutrophils, mast cells, eosinophils and activated T lymphocytes.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Complement Component C3aR Antibody (hC3aRZ1)

Application
Recommended Usage

Flow Cytometry

1:10-1:20

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Complement Component C3aR

The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.

Long Name

Complement Component C3a Receptor

Alternate Names

AZ3B, C3AR, C3AR1, C3R1, Complement Component C3a R

Entrez Gene IDs

719 (Human)

Gene Symbol

C3AR1

UniProt

Q16581

Additional Complement Component C3aR Products

Product Documents for Complement Component C3aR Antibody (hC3aRZ1)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Complement Component C3aR Antibody (hC3aRZ1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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