Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all COPS8 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human CSN8. The immunogen is located within the last 50 amino acids of CSN8. Amino Acid Squence: PLSEPAPVPPIPNEQ

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for COPS8 Antibody - BSA Free

Western Blot: COPS8 AntibodyBSA Free [NBP1-76373]

Western Blot: COPS8 AntibodyBSA Free [NBP1-76373]

Western Blot: COPS8 Antibody [NBP1-76373] - Human liver lysate with COPS8 antibody at 2 ug/ml.

Applications for COPS8 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: COPS8

The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

Alternate Names

COP9, COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis), COP9 homolog, COP9 signalosome complex subunit 8, CSN8JAB1-containing signalosome subunit 8, hCOP9, MGC1297, MMMEP, SGN8MGC43256, Signalosome subunit 8

Gene Symbol

COPS8

UniProt

NP_006701 (Human)

Additional COPS8 Products

Product Documents for COPS8 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for COPS8 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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