CRMP2 Antibody (0A1T1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16406

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP3-16406-100ul
NBP3-16406-20ul
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 0A1T1

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CRMP2 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 473-572 of human CRMP2 (Q16555). PFPDFVYKRIKARSRLAELRGVPRGLYDGPVCEVSVTPKTVTPASSAKTSPAKQQAPPVRNLHQSGFSLSGAQIDDNIPRRTTQRIVAPPGGRANITSLG

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CRMP2 Antibody (0A1T1)

Western Blot: CRMP2 Antibody (0A1T1) [NBP3-16406]

Western Blot: CRMP2 Antibody (0A1T1) [NBP3-16406]

Western Blot: CRMP2 Antibody (0A1T1) [NBP3-16406] - Western blot analysis of extracts of various cell lines, using CRMP2 Rabbit mAb (NBP3-16406) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.
Immunohistochemistry: CRMP2 Antibody (0A1T1) [NBP3-16406]

Immunohistochemistry: CRMP2 Antibody (0A1T1) [NBP3-16406]

Immunohistochemistry: CRMP2 Antibody (0A1T1) [NBP3-16406] - Immunofluorescence analysis of mouse brain using CRMP2 Rabbit mAb (NBP3-16406) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Immunohistochemistry: CRMP2 Antibody (0A1T1) [NBP3-16406]

Immunohistochemistry: CRMP2 Antibody (0A1T1) [NBP3-16406]

Immunohistochemistry: CRMP2 Antibody (0A1T1) [NBP3-16406] - Immunofluorescence analysis of rat brain using CRMP2 Rabbit mAb (NBP3-16406) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Applications for CRMP2 Antibody (0A1T1)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50 - 1:200

Western Blot

1:500 - 1:5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CRMP2

Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease.

Alternate Names

Collapsin response mediator protein 2, CRMP-2, CRMP2N2A3, DHPRP2, dihydropyrimidinase-like 2, dihydropyrimidinase-like 2 long form, dihydropyrimidinase-related protein 2, DRP2collapsin response mediator protein hCRMP-2, DRP-2ULIP-2, ULIP2, Unc-33-like phosphoprotein 2

Gene Symbol

DPYSL2

Additional CRMP2 Products

Product Documents for CRMP2 Antibody (0A1T1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CRMP2 Antibody (0A1T1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.