CSE1L/CAS/Exportin-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38384

Novus Biologicals, part of Bio-Techne
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NBP2-38384
NBP2-38384-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Predicted:

Mouse (95%), Rat (97%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CSE1L/CAS Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: HGITQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATLF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CSE1L/CAS/Exportin-2 Antibody

Immunocytochemistry/ Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384]

Immunocytochemistry/ Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384]

Immunocytochemistry/Immunofluorescence: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human cell line CACO-2 shows positivity in cytoplasm and nucleus but excluded from the nucleoli.
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384]

Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384]

Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human liver.
Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384]

Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384]

Immunohistochemistry-Paraffin: CSE1L/CAS/Exportin-2 Antibody [NBP2-38384] - Staining of human pancreas shows low expression as expected.
View 5 more images

Applications for CSE1L/CAS/Exportin-2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CSE1L/CAS

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.

Long Name

Chromosome segregation 1-like protein

Alternate Names

CAS, CSE1, XPO2

Gene Symbol

CSE1L

UniProt

P55060 (Human)

Additional CSE1L/CAS Products

Product Documents for CSE1L/CAS/Exportin-2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CSE1L/CAS/Exportin-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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