CTPS2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86055

Novus Biologicals, part of Bio-Techne
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NBP1-86055
NBP1-86055-25ul
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Key Product Details

Species Reactivity

Human, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CTPS2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: GVCLGMQLAVIEFARNCLNLKDADSTEFRPNAPVPLVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRHRFEVNPNLIKQFEQNDLSFVGQDVDGD

Reactivity Notes

Reactivity reported in scientific literature (PMID: 24870241). Mouse (86%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CTPS2 Antibody

Western Blot: CTPS2 Antibody [NBP1-86055]

Western Blot: CTPS2 Antibody [NBP1-86055]

Western Blot: CTPS2 Antibody [NBP1-86055] - Analysis in rat cell line NBT-II.
Immunocytochemistry/ Immunofluorescence: CTPS2 Antibody [NBP1-86055]

Immunocytochemistry/ Immunofluorescence: CTPS2 Antibody [NBP1-86055]

Immunocytochemistry/Immunofluorescence: CTPS2 Antibody [NBP1-86055] - Staining of human cell line A-431 shows localization to nucleoplasm. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: CTPS2 Antibody [NBP1-86055]

Immunohistochemistry-Paraffin: CTPS2 Antibody [NBP1-86055]

Immunohistochemistry-Paraffin: CTPS2 Antibody [NBP1-86055] - Staining of human prostate shows strong cytoplasmic positivity in glandular cells.
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Applications for CTPS2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CTPS2

The protein encoded by the CTPS2 gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamineto glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play animportant role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA.Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein.Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variantsencoding the same protein have been described for this gene. (provided by RefSeq)

Alternate Names

CTP synthase 2, CTP synthase II, CTP synthetase 2, CTP synthetase isoform, CTP synthetase type 2, cytidine 5'-triphosphate synthetase 2, DKFZp686C17207, EC 6.3.4.2, FLJ43358, MGC32997, UTP-ammonia ligase, UTP--ammonia ligase 2

Gene Symbol

CTPS2

Additional CTPS2 Products

Product Documents for CTPS2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CTPS2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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