CX3CL1/Fractalkine Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76467

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

ELISA, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all CX3CL1/Fractalkine Antibodies »

Product Summary for CX3CL1/Fractalkine Antibody - BSA Free

Immunogen

Antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human CX3CL1. The immunogen is located within amino acids 20 - 70 of CX3CL1. Amino Acid Squence: CSKMTSKIPVALLIHYQQN

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CX3CL1/Fractalkine Antibody - BSA Free

Western Blot: CX3CL1/Fractalkine AntibodyBSA Free [NBP1-76467]

Western Blot: CX3CL1/Fractalkine AntibodyBSA Free [NBP1-76467]

Western Blot: CX3CL1/Fractalkine Antibody [NBP1-76467] - C2C12 cell lysate with CX3CL1 antibody at (A) 0.5, (B) 1 and (C) 2 mg/ml.

Applications for CX3CL1/Fractalkine Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Western Blot

0.5-2 ug/ml
Application Notes
CX3CL1 is ofen observed migrating at 80 - 100 kDa in SDS-PAGE, presumably due to post-translational modification.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CX3CL1/Fractalkine

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-alpha in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1. CX3CL1 is ofen observed migrating at 80 - 100kDa in SDS-PAGE, presumably due to post-translational modification.

Alternate Names

FKN, Fractalkine, Neurotactin

Gene Symbol

CX3CL1

UniProt

AAB50014 (Human)

Additional CX3CL1/Fractalkine Products

Product Documents for CX3CL1/Fractalkine Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CX3CL1/Fractalkine Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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