CXCR7/RDC-1 Antibody [mFluor Violet 450 SE]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24779MFV450

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP2-24779AF350

Alexa Fluor 405

NBP2-24779AF405

Alexa Fluor 488

NBP2-24779AF488

Alexa Fluor 532

NBP2-24779AF532

Alexa Fluor 594

NBP2-24779AF594

Alexa Fluor 647

NBP2-24779AF647

Alexa Fluor 700

NBP2-24779AF700

Alexa Fluor 750

NBP2-24779AF750

Biotin

NBP2-24779B

DyLight 350

NBP2-24779UV

DyLight 405

NBP2-24779V

DyLight 488

NBP2-24779G

DyLight 550

NBP2-24779R

DyLight 594

NBP2-24779DL594

DyLight 650

NBP2-24779C

DyLight 680

NBP2-24779FR

DyLight 755

NBP2-24779IR

FITC

NBP2-24779F

HRP

NBP2-24779H

Janelia Fluor 549

NBP2-24779JF549

Janelia Fluor 646

NBP2-24779JF646

mFluor Violet 500 SE

NBP2-24779MFV500

mFluor Violet 610 SE

NBP2-24779MFV610

Forumulation

Catalog #

BSA Free

NBP2-24779

Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Sheep

Predicted:

Bovine (100%), Equine (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Flow Cytometry (Negative), Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Simple Western, Western Blot

Label

mFluor Violet 450 SE (Excitation = 406 nm, Emission = 445 nm)

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all CXCR7/RDC-1 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding amino acids 106-129 of human CXCR7/RDC1 was used as the immunogen, GenBank NP_064707.1.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CXCR7/RDC-1 Antibody [mFluor Violet 450 SE]

CXCR7/RDC-1 Antibody [mFluor Violet 450 SE] [NBP2-24779MFV450] -

CXCR7/RDC-1 Antibody [mFluor Violet 450 SE] [NBP2-24779MFV450] - Vial of mFluor Violet 450 conjugated antibody. mFluor Violet 450 is optimally excited at 406 nm by the Violet laser (405 nm) and has an emission maximum of 445 nm.

Applications for CXCR7/RDC-1 Antibody [mFluor Violet 450 SE]

Application

Recommended Usage

Flow Cytometry (Negative)

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: CXCR7/RDC-1

CXCR7/RDC-1 is a G protein-coupled receptor (GPCR) member of the CXC subfamily of chemokine receptors. Human CXCR7/RDC-1 is 362 amino acids (aa) in length with a predicted molecular weight of 41 kDa. Mouse and rat CXCR7/RDC-1 share 93% aa sequence identity with the human protein. CXCR7/RDC-1 binds to and acts as a scavenger for CXCL11/I-TAC and CXCL12/SDF-1. CXCR7/RDC-1 can also function as a co-receptor for HIV and SIV. Unlike other chemokine receptors, CXCR7/RDC-1 does not activate G protein signaling, but instead initiates beta-Arrestin-mediated receptor-ligand internalization. Although CXCR7/RDC-1 itself does not activate G protein signaling, the receptor can heterodimerize with CXCR4 to activate G proteins in response to CXCL12/SDF-1 binding. Studies on CXCR7/RDC-1 knockout mice suggest that it is critical for cardiovascular development. While CXCR7/RDC-1 does not appear to signal in normal hematopoietic cells, it is highly expressed in leukemic cells where it activates Akt signaling that promotes cell trafficking and adhesion. CXCR7/RDC-1 also mediates neuronal migration, displays aberrant signaling in astrocytes, and is highly expressed in glioma cells.

Alternate Names

ACKR3, CMKOR1, CXCR7, GPR159, RDC-1

Gene Symbol

ACKR3

Additional CXCR7/RDC-1 Products

Product Documents for CXCR7/RDC-1 Antibody [mFluor Violet 450 SE]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for CXCR7/RDC-1 Antibody [mFluor Violet 450 SE]

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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