Cystatin B/Stefin B Antibody (11H4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26641

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 11H4

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Cystatin B Antibodies »

Product Summary for Cystatin B/Stefin B Antibody (11H4)

Immunogen

A synthesized peptide derived from Human Cystatin B/Stefin B [UniProt P04080]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cystatin B/Stefin B Antibody (11H4)

Cystatin B/Stefin B Antibody (11H4)

Immunocytochemistry/Immunofluorescence: Cystatin B/Stefin B Antibody (11H4) [NBP3-26641] -

Immunocytochemistry/Immunofluorescence: Cystatin B/Stefin B Antibody (11H4) [NBP3-26641] - Staining of Hela cell with Cystatin B/Stefin B Antibody (11H4) at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 591-conjugated Goat Anti-Rabbit IgG (H+L).

Applications for Cystatin B/Stefin B Antibody (11H4)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl and 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: Cystatin B

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).

Alternate Names

CSTB, Stefin B

Gene Symbol

CSTB

Additional Cystatin B Products

Product Documents for Cystatin B/Stefin B Antibody (11H4)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Cystatin B/Stefin B Antibody (11H4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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