The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype.

Alternate Names

CST6

Gene Symbol

CST6

UniProt

NP_082899

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Product Specific Notices for Cystatin E/M/CST6 Antibody (RM0217-6F49) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Cystatin E/M/CST6 Antibody (RM0217-6F49) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-12252

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Product Summary for Cystatin E/M/CST6 Antibody (RM0217-6F49) - Azide and BSA Free

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Background: Cystatin E/M