Cytokeratin 14 Antibody (KRT14/2375) [DyLight 488]

Validated:

DyLight 488 (Excitation = 493 nm, Emission = 518 nm)

Monoclonal Mouse IgG2a Kappa Clone # KRT14/2375

Please see the vial label for concentration. If unlisted please contact technical services.

Recombinant human Cytokeratin 14 fragment (around aa351-472) (exact sequence is proprietary) (Uniprot: P02533)

Cytoplasmic

Cytokeratin 14 (CK14) belongs to the type I (or A or acidic) subfamily of low molecular weight keratins and exists in combination with keratin 5 (type II or B or basic). CK14 is found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.

Squamous Cell Marker

Monoclonal

Mouse

IgG2a Kappa

Protein A or G purified

50mM Sodium Borate

0.05% Sodium Azide

Please see the vial label for concentration. If unlisted please contact technical services.

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Store at 4C in the dark.