Desmocollin-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85711

Novus Biologicals, part of Bio-Techne
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NBP1-85711
NBP1-85711-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Desmocollin-2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: IGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMKENAEVGTTSNGYKAYDPETRSSSGIRYKKLTDPTGWVTIDENTGSIKVFRSLDREAETIKNGIYNITVLASDQGGRTCTGTLGIILQDVNDNS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Desmocollin-2 Antibody

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human colon, esophagus, liver and tonsil using Anti-DSC2 antibody NBP1-85711 (A) shows similar protein distribution across tissues to independent antibody NBP1-85710 (B).
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human cerebral cortex shows no positivity in neurons as expected.
Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711]

Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-85711] - Staining of human liver shows weak membranous positivity in hepatocytes.
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Applications for Desmocollin-2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Desmocollin-2

Desmocollin 2 is encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Alternate Names

ARVD11, CDHF2, Desmocollin2, DG2, DSC2

Gene Symbol

DSC2

Additional Desmocollin-2 Products

Product Documents for Desmocollin-2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Desmocollin-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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