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DNA polymerase theta Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-36950

Novus Biologicals, part of Bio-Techne
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NBP1-36950

Key Product Details

Species Reactivity

Human

Applications

Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

Product Specifications

Immunogen

Peptide with sequence DTHQQLTCSNDES corresponding to internal region according to NP_955452.3.

Epitope

internal region

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Description

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Applications for DNA polymerase theta Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:1000
Application Notes
WB: Preliminary experiments in human brain (cerebellum lysates) and in lysates of HeLa gave no specific signal but low background.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: DNA polymerase theta

DNA polymerase theta, also referred to as POLQ, is highly expressed in the testes. POLQ has a 2,590 amino acid long isoform that is approximately 290kDa and a shorter 1,786 amino acid long isoform that is approximately 198kDa. POLQ is highly expressed in the testes, plays a role in DNA polymerase activity, and may be implicated in interstrand crosslink repair (ICR). Research on DNA polymerase theta has shown a connection to several diseases and disorders including stomach cancer, malaria, breast cancer, tuberculosis, and meningioma. POLQ has also been shown to have interactions with AP2S1.

Alternate Names

DKFZp781A0112, DNA polymerase eta, EC 2.7.7.7, POLHDNA polymerase theta, polymerase (DNA directed), theta, PRO0327

Entrez Gene IDs

10721 (Human)

Gene Symbol

POLQ

Additional DNA polymerase theta Products

Product Documents for DNA polymerase theta Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for DNA polymerase theta Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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