DNAM-1/CD226 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-85001

Novus Biologicals, part of Bio-Techne
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NBP1-85001
NBP1-85001-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all DNAM-1/CD226 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DNAM-1/CD226 Antibody

Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001]

Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001]

Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001] - Staining of human small intestine shows positivity in lymphoid cells.
Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001]

Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001]

Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001] - Staining of human skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001]

Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001]

Immunohistochemistry-Paraffin: DNAM-1/CD226 Antibody [NBP1-85001] - Staining of human spleen shows moderate positivity in lymphoid cells.
View 1 more images

Applications for DNAM-1/CD226 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: DNAM-1/CD226

CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production.

Long Name

DNAX Accessory Molecule 1

Alternate Names

CD226, DNAM1, PTA1, TLiSA1

Gene Symbol

CD226

Additional DNAM-1/CD226 Products

Product Documents for DNAM-1/CD226 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for DNAM-1/CD226 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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