Dopa Decarboxylase/DDC Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-252

Novus Biologicals, part of Bio-Techne
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NB300-252
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Key Product Details

Species Reactivity

Human, Rat, Bovine, Canine, Guinea Pig, Rabbit, Sheep

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Dopa Decarboxylase/DDC Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Accession # P20711

Specificity

Specific for endogenous levels of the ~55 kDa Dopa Decarboxylase/DDC protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Dopa Decarboxylase/DDC Antibody

Western Blot: Dopa Decarboxylase/DDC Antibody [NB300-252]

Western Blot: Dopa Decarboxylase/DDC Antibody [NB300-252]

Western Blot: Dopa Decarboxylase/DDC Antibody [NB300-252] - Analysis of DOPA Decarboxylase, Human in bovine adrenal medulla lysate using this antibody at 1:1000. Showing specific immunolabeling of the ~55k DOPA decarboxylase protein.

Applications for Dopa Decarboxylase/DDC Antibody

Application
Recommended Usage

Western Blot

1:1000
Application Notes
Recognizes DDC in human adrenal medulla and basal ganglia. Use in Immunohistochemistry and Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 28398344).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Dopa Decarboxylase/DDC

DOPA Decarboxylase (aromatic L-amino acid decarboxylase, AADC; DDC) catalyzes the second reaction in the biosynthesis of catecholamines and serotonin (Waymire and Haycock, 2002; Berry et al., 1996; Haycock et al., 2003). It is also involved in the biosynthesis of trace amines. DDC antibodies can therefore be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999).

Alternate Names

AADC, DDC

Entrez Gene IDs

1644 (Human); 24311 (Rat)

Gene Symbol

DDC

UniProt

P20711

Additional Dopa Decarboxylase/DDC Products

Product Documents for Dopa Decarboxylase/DDC Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Dopa Decarboxylase/DDC Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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