Dopamine beta-Hydroxylase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-112

Novus Biologicals, part of Bio-Techne
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NB300-112
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Key Product Details

Species Reactivity

Validated:

Human, Primate

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Sheep IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Dopamine beta-Hydroxylase Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acid residues from the N-terminal region conjugated to KLH. Accession # P09172

Reactivity Notes

Tested in Human and Primate.

Localization

Exists both in a soluble form (in chromaffin granules) and as membrane bound.

Specificity

Specific for endogenous levels of the ~75 kDa Dopamine beta-Hydroxylase protein.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Theoretical MW

75 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Dopamine beta-Hydroxylase Antibody

Western Blot: Dopamine beta-Hydroxylase Antibody [NB300-112]

Western Blot: Dopamine beta-Hydroxylase Antibody [NB300-112]

Western Blot: Dopamine beta Hydroxylase Antibody [NB300-112] - Western blot of human adrenal medulla. The antibody is specific for the ~75 kDa DBH protein.
Western Blot: Dopamine beta-Hydroxylase Antibody [NB300-112]

Western Blot: Dopamine beta-Hydroxylase Antibody [NB300-112]

Western Blot: Dopamine beta Hydroxylase Antibody [NB300-112] - Human adrenal medulla lysate showing specific immunolabeling of the ~75k DBH protein.

Applications for Dopamine beta-Hydroxylase Antibody

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Dopamine beta-Hydroxylase

The production of neurotransmitters is controlled by environmental stimuli, which send signals through second messengers and protein kinase pathways. Regulation of gene expression of dopamine beta hydroxylase and tyrosine hydroxylase, two of the catecholamine biosynthetic enzymes, by cyclic AMP, diacyl glycerol, and Ca2+ leads to increased neurotransmitter biosynthesis. Dopamine beta-hydroxylase catalyzes the conversion of dopamine to noradrenaline and is expressed selectively in noradrenergic and adrenergic neurons in the nervous system. The disruption of the DBH gene is thought to cause changes in development and behavior in certain models. Both DBH and the multiple regulatory pathways of DBH are of increasing research in many neurological diseases.

Alternate Names

DBH, DBM, Dopamine betaHydroxylase, DOPBHY

Entrez Gene IDs

1621 (Human)

Gene Symbol

DBH

UniProt

P09172

Additional Dopamine beta-Hydroxylase Products

Product Documents for Dopamine beta-Hydroxylase Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Dopamine beta-Hydroxylase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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