DPP6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14301

Novus Biologicals, part of Bio-Techne
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NBP3-14301
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Chimpanzee (100%), Primate (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all DPP6 Antibodies »

Product Specifications

Immunogen

Synthetic 18 amino acid peptide near the center of human DPP6.

Epitope

Internal

Reactivity Notes

Expected reactivity based on percent sequence identity: Equine (89%), Bovine (83%)

Specificity

Human DPP6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for DPP6 Antibody

Immunohistochemistry-Paraffin: DPP6 Antibody [NBP3-14301]

Immunohistochemistry-Paraffin: DPP6 Antibody [NBP3-14301]

Immunohistochemistry-Paraffin: DPP6 Antibody [NBP3-14301] - Immunohistochemistry of formalin-fixed, paraffin-embedded human brain, neurons, after heat-induced antigen retrieval.

Applications for DPP6 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: DPP6

The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.

Long Name

Dipeptidyl-peptidase 6

Alternate Names

DPPX

Gene Symbol

DPP6

Additional DPP6 Products

Product Documents for DPP6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for DPP6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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