Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunoprecipitation (Negative), Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all DR1 Antibodies »

Product Summary for DR1 Antibody

Immunogen

The immunogen recognized by this antibody maps to a region between residue 25 and 75 of human down-regulator of transcription 1 using the numbering given in entry NP_001929.1 (GeneID 1810).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for DR1 Antibody

Western Blot: DR1 Antibody [NBP1-03329]

Western Blot: DR1 Antibody [NBP1-03329]

Western Blot: DR1 Antibody [NBP1-03329] - Whole cell lysate (5, 15 and 50 ug) from HeLa cells. Antibody used at 1 ug/ml.

Applications for DR1 Antibody

Application
Recommended Usage

Western Blot

1:2000-1:5000
Application Notes
This antibody is useful for western blot. It is not recommended for immunoprecipitation.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: DR1

DR1 encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq]

Alternate Names

Down-regulator of transcription 1, down-regulator of transcription 1, TBP-binding (negative cofactor 2), NC2, NC2-beta, Negative cofactor 2-beta, protein Dr1, TATA-binding protein-associated phosphoprotein

Entrez Gene IDs

1810 (Human)

Gene Symbol

DR1

UniProt

NP_001929.1 (Human)

Additional DR1 Products

Product Documents for DR1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for DR1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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